Isa 21

The Burden of the Desert of the Sea.”—In chapter 21:1–10, the prophet turns, as it were, from Egypt to the other end of the world political of his day; and looking beyond Assyrian times, foretells the fall of Babylon by the Medes and Persians. Remembering the position of the kingdom of Judah between these great powers of Egypt and Assyria, the latter of which in time gave place to the Babylonian Empire; and remembering also the purpose of God concerning them, as now unfolded in history, the structure of the book of Isaiah is better comprehended; and order and connection appear where otherwise it would not be seen. It was natural, we might almost say, for the prophet, having recorded the downfall of Egypt before Assyria, to go on to the downfall of Babylon, which in turn gained supremacy over Nineveh.

Robert Roberts, & Walker, C. C. (1907). The Ministry of the Prophets: Isaiah (362–363